The cannabinoid cannabidiol (CBD) is popular among users due to its therapeutic and medical benefits. This is mainly because of its positive effect on the endocannabinoid system (ECS), which is a network of neurotransmitters and chemical messengers spread throughout our bodies. Apart from this, it also influences 60 other molecular pathways to produce its effects, and it is also the reason for the entourage effect of full-spectrum CBD products like oils, tinctures, vape, pills, capsules, etc. In this article, we will investigate the effects of CBD on different receptor complexes, read on to know more about them.
Effect Of Cannabidiol (CBD) On Serotonin
One of the major reasons for CBD’s anxiety-reducing effect is because it increases serotonin levels in the brain. This neurotransmitter has a significant effect on homeostasis, this is because CBD modulates the behavior of 5-HT serotonin receptors. Apart from the brain, these receptors are also present in the gastrointestinal tract and influence GI functions. Because of these reasons, CBD is useful for treating different types of anxiety disorders, schizophrenia symptoms, gut issues, and more.
Effect Of CBD On Receptor Complexes
CBD health benefits are mainly due to its interaction with CB1 and CB2 receptors of the endocannabinoid system (ECS). CB1 receptors are mainly found in the central and peripheral nervous systems, while CB2 receptors are associated with the immune system. The anxiolytic, anticonvulsive, and calm-inducing effects of cannabidiol products are due to its effect on the CB1 receptors. The anti-inflammatory effect of CBD is due to its effect on the CB2 receptors because inflammation is mainly an immune response.
The 5-HT receptors are the link between the endocannabinoid system (ECS) and the serotonergic systems, and it belongs to the huge family of G-protein coupled receptors. Because CBD influences this receptor complex, it reduces pain, anxiety, nausea, vomiting, and headaches. Moreover, keep in mind that all modern pharmaceutical drugs target this G-protein coupled receptors for their therapeutic and medical effects.
Crosstalk Between Endocannabinoid And Serotonergic Systems
It has been found from studies that extensive crosstalk and feedback exists between the endocannabinoid and serotonergic systems. Because of this, CBD also increases levels of another major neurotransmitter, anandamide. This has the effects of improving mood as anandamide brings about bliss. Besides, this is achieved by cannabidiol (CBD) acting as a reuptake inhibitor of this neurotransmitter at the synaptic cleft, i.e. the space that separates two neurons and this is where they communicate with each other. The other major effect of the crosstalk and feedback between the endocannabinoid and serotonergic systems is the reason for CBD reducing blood pressure through its vasodilatory effect.
These are some of the facts that you should know about the effect of cannabidiol (CBD) on the receptor complexes.